Systemic administration of a novel octapeptide, amylin-(1O8), increases bone volume in male mice
نویسندگان
چکیده
JILLIAN CORNISH, KAREN E. CALLON, JUERG A. GASSER, USHA BAVA, EDITH M. GARDINER, DAVID H. COY, GARTH J. S. COOPER, AND IAN R. REID Department of Medicine, School of Biological Sciences, University of Auckland, Auckland 1001, New Zealand; Bone Metabolism Unit, Novartis Pharma, Basel CH-4002, Switzerland; Garvan Institute, Sydney NSW 2010, Australia; and Peptide Research Laboratories, Tulane University Medical Center, New Orleans, Louisiana 70112
منابع مشابه
Systemic administration of a novel octapeptide, amylin-(1---8), increases bone volume in male mice.
Amylin increases bone mass when administered systemically to mice. However, because of its size, the full peptide is not an ideal candidate for the therapy of osteoporosis. The fragment, amylin-(1---8), stimulates osteoblast proliferation in vitro, although it is without effect on carbohydrate metabolism. The present study assessed the effects of daily administration of this peptide on sexually...
متن کاملSystemic administration of amylin increases bone mass, linear growth, and adiposity in adult male mice.
Amylin is a peptide hormone cosecreted with insulin from the pancreatic β-cells that can act as an osteoblast mitogen and as an inhibitor of bone resorption. The effects on bone of its systemic administration are uncertain. The present study addresses this question in adult male mice that were given daily subcutaneous injections of amylin (10.5 μg) or vehicle ( n = 20 in each group) for 4 wk. H...
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Amylin and adrenomedullin are related peptides with some homology to both calcitonin and calcitonin gene-related peptide (CGRP). All these peptides have in common a 6-amino acid ring structure at the amino-terminus created by a disulfide bond. In addition, the carboxy-termini are amidated. Both amylin and adrenomedullin have recently been found to stimulate the proliferation of osteoblasts in v...
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